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The fundamental challenge scientifically is how to
2018-11-07
The fundamental challenge, scientifically, is how to simplify, but not to -simplify. On the one hand, scientific progress requires parsing complexity, ideally into falsifiable hypotheses that can be addressed within well-designed empirical studies. On the other hand, slicing too narrowly is likely t
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Two key findings are as follows First
2018-11-07
Two key findings are as follows: First, motor threshold values do not differ in individuals with TS relative to matched controls (Orth, 2009) (c.f. reference (Orth and Rothwell, 2009)). Importantly, it is suggested that equivalent RMTs in TS patients and controls indicates that neural populations re
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In addition individuals who experienced CSA
2018-11-07
In addition, individuals who experienced CSA and who develop CSA-related Post-Traumatic Stress Disorder (PTSD) are at increased risk to develop subsequent internalizing disorders (Lindert et al., 2014), which makes internalizing disorders and CSA-related PTSD overlapping in symptomatology. This, in
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Similarly in human participants there is evidence of hippoca
2018-11-07
Similarly, in human participants, there is evidence of hippocampal activation as measured by magnetoencephalography (MEG) during performance of transverse patterning (Hanlon et al., 2003; Moses et al., 2009). Interestingly, hippocampal activity decreased and MTL cortical activity increased when sema
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Some groups have reported a history of smoking having a
2018-11-06
Some groups have reported a history of smoking, having a BMI of less than 23 kg/m2, previous unilateral inguinal hernioplasty, postoperative anastomotic stricture, and prolonged use of self-retaining retractor during operation as risk factors of post-RP IH formation. However, Abe et al reported that
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br Discussion Several organ systems can be
2018-11-06
Discussion Several organ systems can be affected by marathon running. Most problems that have been mentioned involve the musculoskeletal, gastrointestinal, cardiac, renal, and pulmonary systems, and also include electrolyte and fluid imbalance, but seldom soft-tissue infections. Because marathon
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br Results Three cases were diagnosed as TEN associated with
2018-11-06
Results Three cases were diagnosed as TEN associated with M. pneumoniae and two were diagnosed as TEN associated with herpes simplex virus infection (Table 2). The presence of these viruses was confirmed by positive serologic findings. The patients consisted of three boys and two girls, with an a
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Radiological investigations are nonspecific and may
2018-11-06
Radiological investigations are nonspecific and may mimic various other benign or malignant conditions. Numerous other diseases show lesions of a variable density with a peripheral enhancement on abdominal CT scans. Areas of focal calcification and liquefactive necrosis, indicating simultaneously e
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br Prevention by management If a parasite
2018-11-06
Prevention by management If a parasite-free status of certain sea-food types can be documented the risk of anisakidosis should be significantly reduced. This may allow for the lifting of freezing regulations which are currently needed to inactivate anisakids. Aquacultured fish such as marine-cult
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Clinically anti inflammatory agents are used to
2018-11-06
Clinically, anti-inflammatory agents are used to relieve the symptoms of gout, and XO inhibitors are used to block the synthesis of uric acid. These two approaches are common treatments of gout. Allopurinol, a purine analog, is the most common XO inhibitor that functions to reduce serum urate level
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br Clinical trials of ketogenic diets in AD Oral
2018-11-06
Clinical trials of ketogenic diets in AD Oral administration of medium chain triglycerides has been shown to induce ketosis in humans [66]. Due to their short fatty arginase inhibitors chain lengths, medium chain trigycerides do not underlie the regulation imposed on long chain fatty acids and t
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Owing to their extremely complex anatomical structures
2018-11-06
Owing to their extremely complex anatomical structures in mammals and humans, identification of stem cell niches has proven to be difficult (Li and Xie, 2005). Consequently, in vivo studies to elucidate signals that regulate stem cell activity suffered from this circumstance. Medical application of
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br Results br Discussion These results are in line with
2018-11-06
Results Discussion These results are in line with the known strong immunosuppressive effects of extracellular adenosine accumulation, mediated mainly through ADORA2A adenosine receptors (Sitkovsky and Ohta, 2005), and with previous reports showing the role of adenosine production by Tregs in i
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phalloidin Because many growth factors function in a context
2018-11-06
Because many growth factors function in a context-dependent manner, we explored the effects of adding WNT3A to the MC on the growth of Bl-CFCs. In cultures containing a combination of hematopoietic growth factors (VEGF, SCF, IL-3, IL-6, thrombopoietin [TPO], EPO, and FLT3L), 0.2%–0.6% of phalloidin
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The following are the supplementary data
2018-11-06
The following are the supplementary data related to this article. Acknowledgments This work was supported by Marie-Curie IEF FellowshipPIEF-GA-2009-254644 (J.F.) and the Netherlands Institute for Regenerative Medicine (NIRM) (E.W., M. vd. B. and T.N.). Introduction Human ES (hES) cells are p
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