• Modulation of GASZ by ectopic overexpression

  2018-11-08

  

  Modulation of GASZ by ectopic overexpression or by RNA interference in ESCs affected several key germ cell markers, such as Oct4, Dazl, Mvh, Miwi, and Mili, which may in turn contribute to the altered PGC or EGC derivation from differentiated EBs. Since GASZ is localized in the intermitochondria cem

• 8-Bromo-cAMP, sodium salt br Materials and methods br Resul

  2018-11-08

  

  Materials and methods Results Discussion We report that while MM are randomly distributed within BM, 15-h post-transplant, HSC (LSKSLAM cells) preferentially home to be within two 8-Bromo-cAMP, sodium salt of MM. To investigate whether these two cell types could influence the biology of t

• dihydrochloride In this study localization of the

  2018-11-08

  

  In this study, localization of the SSC population was determined by PGP 9.5 expression. PGP 9.5, also called ubiquitin C-terminal hydrolase L-1, is expressed in neuronal dihydrochloride and testes, and specific expression of PGP9.5 was identified in spermatogonia of day 8 and 16 mice, and PGP9.5 exp

• The following are the supplementary data

  2018-11-08

  

  The following are the supplementary data related to this article. Contribution statement O.K., J.J.K. and Y.K. participated in designing the experiments, execution of described works, statistical analysis, interpretation of data and writing the manuscript. H.-S.K., M.H., O.E., C.L., C.V. and T.

• However unabated in vivo cell proliferation can be problemat

  2018-11-08

  

  However, unabated in vivo cell proliferation can be problematic and often has undesired consequences such as tumor formation. CNS transplantation of highly proliferative hESCs and immature neural progenitors (Brederlau et al., 2006; Seminatore et al., 2010), as well as known neural tumor-forming cel

• The low density lipoprotein receptor related protein LRP fam

  2018-11-08

  

  The low-density lipoprotein receptor-related protein (LRP) family is an evolutionarily conserved group of cell-surface receptors that regulate diverse biological functions in different organs, tissues, and cell types, in mammals and species of other taxa (Strickland et al., 1994; Croy et al., 2003).

• Yamazaki et al showed that PTCH receptor expression was obse

  2018-11-08

  

  Yamazaki et al. showed that PTCH receptor expression was observed in cultured human peripheral blood-derived endothelial progenitor cells (EPCs) but not in mature endothelial cells (Yamazaki et al., 2008), suggesting that SHh might have a certain effect on human EPCs and CD34+ cells. Indeed, recent

• Dibromo chloropropane DBCP is a banned

  2018-11-08

  

  1,2-Dibromo-3-chloropropane (DBCP) is a banned nematicide that has been shown to cause male infertility (Amann and Berndtson, 1986; Bjorge et al., 1995; Holme et al., 1991; Potashnik and Porath, 1995; Slutsky et al., 1999; Whorton et al., 1979). In exposed workers, DBCP is gonadotoxic resulting in a

• Taken together our findings support the hypothesis that AM

  2018-11-08

  

  Taken together, our findings support the hypothesis that AM can rescue OPC differentiation via receptor-mediated Akt signaling. However, there are some important caveats to keep in mind. First, our current study used only a pure cell culture system. However, to prove clinically-relevant supportive/p

• Osteoarthritis OA is a common joint disease

  2018-11-08

  

  Osteoarthritis (OA) is a common joint disease associated with articular cartilage degeneration. To improve the therapeutic options of OA, tissue engineering based on the use of hBMSCs has become prominent; however, the presence of inflammatory cytokines, such as interleukin-1β (IL-1β), during the ch

• cycloastragenol Expression of pluripotency markers was exami

  2018-11-08

  

  Expression of pluripotency markers was examined by immunocytochemistry staining, using cycloastragenol against human OCT3/4, E-CADHERIN, and NANOG (Fig. 1A). The in vitro spontaneous differentiation potential towards the three germ layer of the BIOT-0726-LOAD iPSC line was demonstrated by the expre

• br Author disclosure statement br Acknowledgements Authors

  2018-11-08

  

  Author disclosure statement Acknowledgements Authors would like to thank Dr. T. Ramakrishna Murti for his valuable comments and linguistic corrections in the manuscript. Authors would also like to thank D.I Biotech (Seoul, Korea) for support to analyze neurite outgrowth. This work was supporte

• br Materials and methods br Results

  2018-11-08

  

  Materials and methods Results Discussion The effect of donor MSCs in tumor growth remains controversial (Cho et al., 2009). Discrepancies concerned to whether they promote or suppress it may be due to disparities in cell source, isolation and expansion conditions, via and timing of administ

• In the work we present here we investigated how miR

  2018-11-08

  

  In the work we present here, we investigated how miR-29a influences iPSC generation in mouse and we analyzed canonical WNT signaling pathway and the pluripotency-related active DNA demethylation enzyme Tet1 in this context, both of which are known to be modulated by miR-29. Furthermore, we show evid

• oxycodone hydrochloride We have found a rare population

  2018-11-08

  

  We have found a rare population of pNSCs in the adult mammalian brain (termed AdpNSCs). We isolated cells from the adult periventricular region that generate clonally derived, self-renewing, and multipotent colonies in vitro in the presence of LIF. These LIF colonies can be passaged to give rise to

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