• In the present study enzyme

  2018-10-24

  

  In the present study, enzyme activity was dispensable for reprogramming and iPSC maintenance. This is in contrast with Fanconi anemia (Raya et al., 2009; Navarro et al., 2014), and also with Sanfilippo type B (Lemonnier et al., 2011) and Pompe disease (Higuchi et al., 2014), in all of which gene com

• br Results br Discussion Genomic instability is

  2018-10-24

  

  Results Discussion Genomic instability is one of the biggest concerns in the potential clinical use of iPSCs (Rocha et al., 2013). The challenging field of regenerative medicine requires an in-depth understanding of the causes and consequences of genetic abnormalities that arise during the rep

• Overall our data support the view

  2018-10-24

  

  Overall, our data support the view that the SEZ is a source of plasticity for the adult CC, and that oligodendroblasts could be a valid therapeutic tool for demyelinating diseases if their generation from wider parts of the SEZ could be stimulated, if their response could be sustained for long perio

• computed from the surface area was The shape of the

  2018-10-24

  

  computed from the surface area, was 75 %. The shape of the stenosis was non-axisymmetric and was described by the formulae for the upper (x) and the lower (x) borders of the stenosis in the mean longitudinal cross-section: where .where R is the radius of the tube; φ are the mean flow, the axial an

• The acoustically opaque hood for the

  2018-10-24

  

  The acoustically opaque hood for the MF (Fig. 3) was made in the shape of the dolphin\'s rostrum and was snugly fit over it. The length of the hood was about 15cm. It was made from a 5 mm-thick sheet of neoprene foam with closed pores. This material has a high strength and high water and oil resista

• One of the main innovations of this

  2018-10-24

  

  One of the main innovations of this assessment of SRCB was the explicit incorporation of both stress-reduction as a motivation for engaging in the behavior and the perceived effectiveness of that behavior at relieving emotional distress. This stands in sharp glucocorticoid receptors to most epidemi

• br It has been recognised

  2018-10-23

  

  It has been recognised that up to 25% of breast cancer overexpresses the transmembrane human epidermal growth factor receptor 2 (HER2), which, in the absence of treatment, is associated with an adverse prognosis for patients . The monoclonal antibody trastuzumab, which targets the HER2 receptor, h

• TILDA does not rely on

  2018-10-23

  

  TILDA does not rely on the amplification of viral replication and offers similar advantages of the DNA PCR assays with regard to simplicity and small blood volume requirement. It does not require RNA extraction and 96-well plates with serially diluted potassium phosphate monobasic can be stored at

• We identified an acquired ceritinib

  2018-10-23

  

  We identified an acquired ceritinib-resistance mechanism caused by P-gp overexpression in an ALK-rearranged NSCLC patient who was receiving ceritinib therapy. We also demonstrated that ceritinib is a P-gp substrate and that P-gp inhibition reversed ceritinib and crizotinib resistance. While our manu

• The cAMP pathway has been

  2018-10-23

  

  The cAMP pathway has been implicated in physiological and pathological learning, but cognitive enhancement in healthy individuals has not been previously observed. In Drosophila, cAMP signaling during development is required for fine-tuning mushroom-body output neurons, a key component of learning a

• In order to test the effect of anti

  2018-10-23

  

  In order to test the effect of anti-merozoite Sennoside A in complement-mediated RBC invasion we used two types of antibodies, an anti-merozoite mouse monoclonal (mAb5.2) and polyclonal IgG from MSP142 vaccines (Otsyula et al., 2013). Use of mAb5.2 resulted in enhancement of RBC invasion above that

• Stratifying patients according to the toxicity risk and

  2018-10-23

  

  Stratifying patients according to the toxicity risk and modulating EBRT dose would provide a valuable tool for personalized EBRT (). Many efforts have been made to develop assays capable of predicting susceptibility for the development of radiation injury that finally allow customization of EBRT pro

• A technique recently developed for in

  2018-10-23

  

  A technique recently developed for in vitro amplification of prions, the RT-QuIC (quaking-induced conversion) assay, is a highly sensitive and specific technique that can detect small amounts of prion-seeding activity (Takatsuki et al., 2015). In our study, the detection limit of the RT-QuIC assay w

• Another issue raised by the IDSA

  2018-10-23

  

  Another issue raised by the IDSA and others is the urgent need to establish a national FMT registry in order to monitor safety and long-term adverse events of FMT (Hecht et al., 2014; Vyas et al., 2015). Earlier this year, the American Gastroenterological Association (AGA) received funding from the

• Another group has recently found

  2018-10-23

  

  Another group has recently found that miRNA-146a, by targeting of TRAF6, could suppress of M1 marker smad inhibitor in the context of tuberculosis (). The current work from He and colleagues extend these findings by showing that miRNA-146 expression by macrophages can be regulated by type 2 cytokin

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