• One attractive strategy to improve outcome in heart failure

  2018-10-24

  

  One attractive strategy to improve outcome in heart failure is to regenerate damaged myocardium by making more functional cardiomyocytes. Extensive work over the past two decades has overturned the prevailing dogma that adult cardiomyocytes do not undergo cell division by demonstrating that adult ca

• We next aimed to test the differentiation capabilities

  2018-10-24

  

  We next aimed to test the differentiation capabilities of the EZ spheres. We found that at any passage for all cell lines regardless of cryopreservation, EZ spheres can be placed in specific neural induction media for terminal neuronal or glial cell differentiation using protocols adapted from those

• Our study reports that the loss of

  2018-10-24

  

  Our study reports that the loss of Klf5 from intestinal stem pitavastatin leads to reduction in proliferation eventually resulting in the loss of stem cells. We propose three possible outcomes of Klf5 deletion in stem cells that could elucidate our findings. Firstly, the replenishment of the TA cel

• It has been hypothesized that neurogenesis

  2018-10-24

  

  It has been hypothesized that neurogenesis in DG may play an important role in learning and memory and especially in spatial memory (Deng et al., 2010; Jessberger et al., 2009; Piatti et al., 2013). In the present study, mice with AQ treatment showed an increased percentage of spontaneous alternatio

• The original XO karyotype Fig of

  2018-10-24

  

  The original 45 XO karyotype (Fig. 1) of the donor CVCs was maintained in TS ViPSCs even after prolonged maintenance (passage 25) indicating that the process of reprogramming with episomal vectors and in vitro culture conditions did not alter this iPSC line chromosomally. The iPSC line established i

• We also found clear differences in the amount

  2018-10-24

  

  We also found clear differences in the amount of stress fibers between the perivascular derivatives. Abundant stress fibers were found in con-vSMCs located throughout the entire cell body. While hiPSC syn-vSMCs had fewer stress fibers, pericyte derivatives demonstrated the lowest levels of stress fi

• equol br Experimental Procedures br Author Contributions br

  2018-10-24

  

  Experimental Procedures Author Contributions Acknowledgments Introduction The reprogramming of somatic cells to induced pluripotent stem cells (iPSCs) has revolutionized the fields of biology and medicine, providing new avenues for research and regenerative medicine applications. IPSCs a

• During embryonic development retinoic acid

  2018-10-24

  

  During embryonic development, retinoic concentration equation (RA) acts as a morphogen, providing signals that instruct commitment of unspecified precursors toward separate cell fates, thereby helping to mediate tissue patterning and organogenesis (Duester, 2008; Kumar and Duester, 2011; Ross et al

• In the present study enzyme

  2018-10-24

  

  In the present study, enzyme activity was dispensable for reprogramming and iPSC maintenance. This is in contrast with Fanconi anemia (Raya et al., 2009; Navarro et al., 2014), and also with Sanfilippo type B (Lemonnier et al., 2011) and Pompe disease (Higuchi et al., 2014), in all of which gene com

• br Results br Discussion Genomic instability is

  2018-10-24

  

  Results Discussion Genomic instability is one of the biggest concerns in the potential clinical use of iPSCs (Rocha et al., 2013). The challenging field of regenerative medicine requires an in-depth understanding of the causes and consequences of genetic abnormalities that arise during the rep

• Overall our data support the view

  2018-10-24

  

  Overall, our data support the view that the SEZ is a source of plasticity for the adult CC, and that oligodendroblasts could be a valid therapeutic tool for demyelinating diseases if their generation from wider parts of the SEZ could be stimulated, if their response could be sustained for long perio

• computed from the surface area was The shape of the

  2018-10-24

  

  computed from the surface area, was 75 %. The shape of the stenosis was non-axisymmetric and was described by the formulae for the upper (x) and the lower (x) borders of the stenosis in the mean longitudinal cross-section: where .where R is the radius of the tube; φ are the mean flow, the axial an

• The acoustically opaque hood for the

  2018-10-24

  

  The acoustically opaque hood for the MF (Fig. 3) was made in the shape of the dolphin\'s rostrum and was snugly fit over it. The length of the hood was about 15cm. It was made from a 5 mm-thick sheet of neoprene foam with closed pores. This material has a high strength and high water and oil resista

• One of the main innovations of this

  2018-10-24

  

  One of the main innovations of this assessment of SRCB was the explicit incorporation of both stress-reduction as a motivation for engaging in the behavior and the perceived effectiveness of that behavior at relieving emotional distress. This stands in sharp glucocorticoid receptors to most epidemi

• br It has been recognised

  2018-10-23

  

  It has been recognised that up to 25% of breast cancer overexpresses the transmembrane human epidermal growth factor receptor 2 (HER2), which, in the absence of treatment, is associated with an adverse prognosis for patients . The monoclonal antibody trastuzumab, which targets the HER2 receptor, h

13384 records 888/893 page Previous Next First page 上5页 886887888889890 下5页 Last page